Prostate Cancer by MWEWA MUSONDA - Oncology-unza

Description

This detailed oncology presentation on prostate cancer covers the pathophysiology, risk factors, diagnostic parameters, and comprehensive treatment modalities for this common malignancy. The material outlines the molecular basis involving mutations in p53, BCL2, and Akt kinase signaling, alongside the role of androgens in disease progression. Key diagnostic tools such as Prostate-Specific Antigen (PSA) testing, digital rectal examination, biopsy with Gleason scoring, and imaging (MRI/CT) are explained for staging and metastasis evaluation. Treatment strategies range from surgery (prostatectomy) and radiotherapy to advanced hormonal therapies including Luteinizing Hormone blockers, anti-androgens, triple androgen blockade, and novel agents like enzalutamide and abiraterone. Chemotherapy options for castrate-resistant disease and bone-targeted therapies like radium-223 are also discussed. This resource is essential for medical students, oncology trainees, and practitioners in Zambia, providing structured, exam-focused content for understanding prostate cancer management within a tertiary medical education framework. Download these comprehensive notes for thorough preparation and clinical insights.