Cervical Cancer by RUTH MTONGA - University of Zambia School of Medicine - Obstetrics & Gynecology-unza

Description

This detailed academic presentation on cervical cancer provides a comprehensive overview of its etiology, pathophysiology, clinical presentation, diagnostic workup, and stage-based management. The material highlights the central role of persistent high-risk HPV infection (notably types 16, 18, and 45) in carcinogenesis, facilitated by viral proteins E6 and E7 that inactivate tumor suppressors p53 and Rb. Key risk factors include early sexual activity, multiple partners, immunosuppression (e.g., HIV), smoking, and lack of screening. Clinical features such as irregular vaginal bleeding, discharge, and pelvic pain are outlined, alongside diagnostic steps from Pap smear and colposcopy to imaging and biopsy. Treatment strategies range from local excision for early-stage disease to chemoradiation for advanced stages, with emphasis on HPV vaccination for prevention. This resource is essential for medical students, obstetrics and gynecology trainees, and practitioners in Zambia, offering structured, exam-focused content for understanding cervical cancer within a tertiary medical education context. Download these comprehensive notes for thorough preparation and clinical insights.