LOCAL ANAESTHESIA by Dr. Sindwa Kanyimba (BSc, MBChB, MSc) - University of Zambia School of Medicine - Neuropharmacology-unza

Description

This lecture covers the fundamental principles of local anaesthesia, delivered by Dr. Sindwa Kanyimba for the MBChB program at the University of Zambia School of Medicine. It details the mechanism of action, explaining how local anaesthetics reversibly bind to sodium channels to inhibit nerve conduction and produce reversible block. The material outlines the physiologic factors influencing activity, such as lipid solubility, protein binding, and percent ionization, including how pH affects onset. It classifies local anaesthetics into esters and amides, noting their metabolism and allergic potential, and describes various administration techniques including surface application, infiltration, nerve blocks, and regional methods. The choice of agent based on duration of action is discussed, with lignocaine highlighted as the most widely used intermediate-acting agent. This resource is designed for medical students and junior doctors seeking to understand the pharmacology and clinical application of local anaesthetics for safe and effective pain management. Review this comprehensive guide to strengthen your foundational knowledge in anaesthetic practice.