Approach to Anaemia II by Dr. CK Mwandama - University Teaching Hospital, Lusaka - Haematology-UTH

Description

This comprehensive academic lecture on the diagnostic approach to anaemia, authored by Dr. CK Mwandama from the Haematology Unit within the Department of Internal Medicine at the University Teaching Hospital (UTH) in Lusaka, provides a systematic and in-depth review of various anaemia subtypes. The presentation outlines a clear algorithmic methodology for evaluating microcytic, macrocytic, and normocytic anaemias, serving as a crucial framework for clinical decision-making. It delves into the detailed pathogenesis, clinical features, and evidence-based management of specific deficiencies, including iron deficiency anaemia, vitamin B12 deficiency (with a focus on pernicious anaemia), and folate deficiency. The lecture also covers the complex pathophysiology of anaemia of chronic disease (AOCD), explaining the role of cytokines and hepcidin in iron sequestration and erythropoiesis suppression, and reviews the classification, mechanisms, and treatment of autoimmune haemolytic anaemias (AIHA). For each condition, the material discusses key investigations, such as iron studies, serum B12 and folate levels, direct antiglobulin tests, and bone marrow findings, alongside therapeutic strategies ranging from oral iron supplementation and intramuscular hydroxocobalamin to corticosteroids and immunosuppressive agents. This resource is essential for medical students, postgraduate trainees in internal medicine and haematology, and practicing clinicians seeking to refine their diagnostic skills and therapeutic approach to this common clinical presentation. It serves as a valuable study and reference guide for both exam preparation and clinical practice. Review this detailed presentation to strengthen your systematic evaluation and management of anaemia.