The process by which the columnar epithelium of the endocervix is physiologically replaced by squamous epithelium is called 'squamous metaplasia.' This is a normal, adaptive process that occurs primarily in the transformation zone of the cervix. It begins when the delicate columnar epithelium, which is exposed to the acidic vaginal environment at the external os, is damaged or irritated. Reserve cells beneath the columnar epithelium proliferate and differentiate into immature squamous cells, which then mature into non-keratinized stratified squamous epithelium. This process creates the transformation zone—the area between the original squamocolumnar junction and the new one. Squamous metaplasia is hormonally influenced, being most active during adolescence, pregnancy, and with oral contraceptive use. While it is a normal process, the metaplastic epithelium in the transformation zone is particularly vulnerable to human papillomavirus (HPV) infection, which is why this area is where most cervical precancers and cancers develop.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies