Analytical and Clinical Validation of Diagnostic Tests
Q: When evaluating a diagnostic test, what two performance metrics are most directly threatened if near-expiry controls are used during validation?
Did You Know?
Charcot-Leyden crystals in urine without accompanying eosinophils may indicate previous eosinophilic inflammation, as these crystals persist after eosinophils have degranulated and died. Charcot-Leyden crystals are composed of lysophospholipase from eosinophil granules and can remain in tissues or secretions longer than intact cells. Their presence suggests a history of allergic or parasitic conditions affecting the urinary tract, such as eosinophilic cystitis or schistosomiasis. However, they could also represent contamination from genital secretions (in females) or respiratory secretions. Clinical correlation and search for other evidence of eosinophilia are needed.
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