Albendazole (and other benzimidazoles like mebendazole) exerts its anthelmintic effect by selectively binding to parasite beta-tubulin, a structural protein. This binding inhibits the polymerization of microtubules—dynamic cytoskeletal structures essential for numerous cellular functions. The disruption of microtubule assembly has several deleterious effects on the parasite: 1) It impairs glucose uptake by damaging the tegument/intestine of the worm. 2) It blocks intracellular transport. 3) It inhibits cell division (mitosis). Ultimately, this leads to depletion of energy stores (glycogen) and paralysis, followed by death and expulsion of the worm. The drug's selective toxicity arises because it binds with much higher affinity to parasite beta-tubulin than to mammalian beta-tubulin. It does not primarily act on calcium channels (A), neuromuscular junctions (B), or DNA synthesis (D).

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Zambia

• loveness Phiri – 801 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies