Benign Disorders of White Blood Cells
Q: What condition is characterized by an isolated, persistent increase in the eosinophil count in the peripheral blood?
Did You Know?
Parabasal cells represent an early stage in the maturation of squamous epithelium. They are round to oval in shape, typically measuring 15-25 μm in diameter. Their cytoplasm is dense and stains deeply basophilic (blue) with Pap stain. The nucleus is round to oval, vesicular (with fine, evenly distributed chromatin), and occupies approximately half of the cell volume, giving a nuclear-to-cytoplasmic ratio of about 1:1 to 1:2. These cells may occasionally show small cytoplasmic vacuoles. Parabasal cells are not polygonal (that's intermediate and superficial cells), their nuclei are not pyknotic (that's superficial cells), and they do not have abundant pale cytoplasm (that would be more characteristic of histiocytes or glycogen-filled cells in pregnancy). Their presence as the predominant cell type typically indicates an atrophic pattern, often seen in postmenopausal women or in low-estrogen states.
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