Elk-1 is a member of the ETS family of transcription factors and is a primary nuclear target of activated ERK. ERK phosphorylates Elk-1 on multiple serine residues. This phosphorylation enhances the ability of Elk-1 to form a ternary complex with Serum Response Factor (SRF) on the Serum Response Element (SRE) in the promoters of immediate-early genes such as c-Fos. The induction of c-Fos is a rapid response that contributes to longer-term changes in gene expression driving cell proliferation.

Break down complex topics into smaller, manageable chunks for easier recall.

Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies