Myelofibrosis is a myeloproliferative neoplasm where the normal, soft bone marrow tissue is gradually replaced by fibrous (scar) tissue. This scarring disrupts normal blood cell production. As a result, the blood cells that are made are often abnormal in shape and size. A hallmark finding on the peripheral blood film is the presence of teardrop-shaped red blood cells, known as dacrocytes. These oddly shaped cells are formed as the red cells try to squeeze through the fibrotic bone marrow. The blood picture is often described as leukoerythroblastic, showing both immature white cells (myelocytes) and nucleated red blood cells (erythroblasts) alongside the teardrop cells, reflecting the bone marrow's disorganized and stressed state.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies