Cadmium Toxicology

question 1 of 6 course: Biomedical Science(Degree)
question 1 of 6 course: Biomedical Science(Degree)

Q: Which heavy metal is associated with 'Itai-Itai' disease?

Did You Know?

True. A healthy vaginal environment is maintained at an acidic pH (around 3.8-4.5) by lactobacilli, which produce lactic acid from glycogen in epithelial cells. Trichomonas vaginalis disrupts this balance. The parasite consumes vaginal epithelial cells and glycogen, directly reducing the substrate available for lactobacilli. It also causes inflammation and an influx of white blood cells. The combination of reduced lactobacilli and increased cellular debris raises the vaginal pH to a more neutral or alkaline level (often >4.5). This altered environment is less hospitable to the normal protective flora but more favorable for the growth of other pathogens, such as Gardnerella vaginalis (associated with bacterial vaginosis), anaerobic bacteria, and possibly facilitating the acquisition or persistence of other sexually transmitted infections like HIV. Thus, trichomoniasis creates a dysbiotic state that can lead to mixed infections.

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