True. Prolactin secretion from the anterior pituitary is unique among the anterior pituitary hormones in that its primary hypothalamic control is inhibitory. Dopamine, produced by neurons in the arcuate nucleus of the hypothalamus, is the major Prolactin-Inhibiting Factor (PIF). It is secreted into the hypothalamic-pituitary portal blood vessels and travels to the anterior pituitary, where it binds to D2 receptors on lactotroph cells, suppressing prolactin synthesis and release. Therefore, any factor that reduces dopamine release or blocks its receptors (like certain antipsychotic drugs) can lead to hyperprolactinemia. Suckling during breastfeeding is a key stimulus for prolactin release; it inhibits dopamine secretion, thereby allowing prolactin levels to rise. Other factors like TRH and stress can stimulate prolactin release, but dopamine is the dominant regulator.

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Zambia

• ivwananji siwale – 29 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies