Sulfasalazine, used for inflammatory bowel disease and rheumatoid arthritis, can cause orange-yellow discoloration of urine and may form needle-shaped crystals similar to other sulfonamides. Sulfasalazine is metabolized to sulfapyridine and 5-aminosalicylic acid; the sulfapyridine component can crystallize, especially in acidic urine and with dehydration. Crystalluria can lead to nephrolithiasis or obstructive uropathy. Recognition prevents confusion with other crystals and prompts appropriate management (hydration, urine alkalinization, dose adjustment). Patients on sulfasalazine should be advised to maintain good hydration.

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Zambia

• ivwananji siwale – 29 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies