Chemotherapy of Nematode Infections
About this topic
A core topic in medical parasitology for university and diploma students in Zambia, focusing on the treatment of roundworm infections. This module details the pharmacology of major anthelmintic drugs used against nematodes, including Mebendazole, Thiabendazole, Pyrantel Pamoate, Ivermectin, and Diethylcarbamazine. For each drug, the mechanism of action (e.g., disrupting microtubule assembly, causing neuromuscular blockade), spectrum of activity against specific worms (e.g., Ascaris, hookworm, pinworm, Strongyloides, filariae), pharmacokinetics, and adverse effects are covered. Students will learn to match the correct drug to clinical presentations like intestinal obstruction, anemia, or cutaneous larva migrans. This practical knowledge is indispensable for Zambian healthcare students, as intestinal nematodes are highly prevalent, and effective treatment is a key component of public health interventions and clinical management in hospitals and rural health centers.
What you'll practise (1 question)
- Mebendazole acts by inhibiting glucose uptake in parasitic worms, leading to their depletion of energy stores. True or False?
Answer each question above to see the correct answer and a full explanation.