University revision · Molecular Biology and Medical Genetics

Chromosomal Aberrations

Question 1 of 2 Course: Biomedical Science(Degree)

Which of the following are microdeletion syndromes?

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True. The development of adjuvant therapy in the mid-20th century was a paradigm shift based on the 'systemic disease' model of cancer. It recognized that even after seemingly successful radical surgery, many patients relapsed and died from distant metastases. This implied the presence of microscopic tumor cells (micrometastases) that had already spread before surgery. Adjuvant therapy (chemotherapy, radiation, hormone therapy) is given after primary local treatment with the goal of eradicating these undetectable micrometastases, thereby reducing the risk of recurrence and improving cure rates.

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