This statement is false. While allele frequencies in large, stable populations change very slowly over generations, they are not static. They can change due to evolutionary forces such as natural selection, genetic drift, gene flow (migration), and mutation. There is evidence that ABO blood group frequencies have been influenced by selective pressures. For example, some studies suggest that type O might confer a survival advantage against severe malaria or that type A might be linked to increased susceptibility to certain strains of smallpox or plague. Additionally, in modern times, large-scale migration and admixture between previously isolated populations can lead to more rapid changes in local ABO distributions. Therefore, the frequency is dynamic on an evolutionary timescale and can shift with population movements.

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