Diethylstilbestrol (DES) is one of the most tragic and well-documented case studies in reproductive toxicology. It is a synthetic estrogen prescribed to millions of pregnant women from the 1940s to the 1970s, primarily to prevent miscarriage. Decades later, it was discovered that in-utero DES exposure caused severe and lasting harm to the offspring, known as 'DES daughters' and 'DES sons.' In daughters, it led to a rare vaginal clear-cell adenocarcinoma, structural abnormalities of the reproductive tract (like T-shaped uterus), infertility, ectopic pregnancy, and preterm birth. In sons, it was associated with an increased risk of testicular abnormalities, cysts, and possibly subfertility. DES is a powerful lesson on the latent, multi-generational effects of prenatal exposure to endocrine-disrupting chemicals, even when given with therapeutic intent.

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Zambia

• Naomi Miselo – 31 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies