Dehydration and Clearing in Tissue Processing
Q: Chloroform is a clearing agent that is less damaging to tissue but more toxic than xylene.
Did You Know?
The primary risk of transfusing type-specific but non-crossmatched blood (i.e., blood that matches the patient's ABO and Rh type but has not undergone a full compatibility crossmatch) is a hemolytic transfusion reaction due to unexpected antibodies other than anti-A or anti-B. While ABO compatibility is assured, the patient may have developed IgG antibodies against other blood group antigens (e.g., in the Rh, Kell, Kidd, or Duffy systems) from a previous pregnancy or transfusion. These antibodies may not be detectable in the rapid immediate-spin crossmatch used in emergencies. A full crossmatch, which includes an antiglobulin (Coombs) phase, is designed to detect these clinically significant antibodies. Transfusing non-crossmatched blood carries a small but real risk of a delayed hemolytic transfusion reaction, where the donor cells are destroyed days later, potentially causing fever, jaundice, and a drop in hemoglobin.
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