A deficiency of Factor IX is known as Hemophilia B or Christmas disease. It is an X-linked recessive bleeding disorder, clinically very similar to Hemophilia A (Factor VIII deficiency). Patients experience a bleeding tendency that correlates with the severity of the factor deficiency. The hallmark is deep tissue bleeding into muscles and joints (hemarthrosis), which can be spontaneous or occur after minor trauma. This leads to pain, swelling, and, over time, can cause crippling arthropathy (joint damage). Other manifestations include prolonged bleeding after surgery or dental work, and easy bruising. Like Hemophilia A, the bleeding is due to a defect in the intrinsic coagulation pathway, leading to a prolonged APTT, while PT and bleeding time are normal.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies