Hypereosinophilic Syndrome (HES) is defined by a persistent and marked elevation of eosinophils in the blood (typically >1500 cells/μL) for at least six months, where other common causes of eosinophilia (like parasitic infections, allergies, or drug reactions) have been ruled out. Crucially, the high eosinophil count causes direct tissue damage and organ dysfunction. Eosinophils release toxic proteins that can injure the heart (leading to fibrosis), nervous system, skin, lungs, and other organs. Diagnosis involves confirming the high eosinophil count, excluding reactive causes, and demonstrating evidence of end-organ damage. It can be idiopathic or driven by a genetic mutation (e.g., FIP1L1-PDGFRA fusion gene).

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies