Fine Needle Aspiration Cytology
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In HPFH, the switch from fetal hemoglobin (HbF) to adult hemoglobin (HbA) is incomplete. Individuals continue to produce significant amounts of HbF into adulthood. This is usually a benign condition. In contrast, conditions like sickle cell disease or beta-thalassemia are characterized by low or abnormal HbA, not high HbF as a primary feature of HPFH.
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