This statement is true. Polymer-based detection systems represent a significant advancement in IHC technology. Instead of relying on the biotin-avidin interaction, these systems use a synthetic polymer backbone, often composed of dextran (a large sugar molecule) or other polymers. Numerous molecules of an enzyme (like HRP or AP) and numerous molecules of secondary antibody are chemically conjugated to this single polymer backbone, creating a large, stable complex. During staining, after the primary antibody is applied, this ready-to-use polymer complex is added in a single step. The secondary antibody components on the polymer bind to the primary antibody. Because each polymer carries dozens of enzyme molecules, a tremendous amount of signal amplification is achieved at the antigen site with just one incubation step. This method is highly sensitive, rapid (two-step procedure), and avoids the problem of endogenous biotin interference that plagues ABC methods. It is now one of the most common detection systems in modern diagnostic laboratories.

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