Forensic Chemistry and Drug Analysis
Q: The Rf value in Thin-Layer Chromatography (TLC) is calculated by dividing the distance traveled by the mobile phase by the distance traveled by the analyte.
Did You Know?
Therapeutic Plasma Exchange (TPE) involves removing a patient's plasma and replacing it with a replacement fluid (e.g., albumin, saline, or fresh frozen plasma). Potential complications include: 1) **Citrate Toxicity**: The anticoagulant citrate (used to prevent clotting in the apheresis circuit) chelates calcium, potentially causing hypocalcemia (tingling, muscle cramps, arrhythmias). 2) **Hypovolemia/Hypervolemia**: From fluid shifts if replacement is not accurately matched. 3) **Allergic Reactions**: To replacement proteins (especially FFP). 4) **Coagulopathy**: Due to removal of clotting factors if not adequately replaced. 5) **Infection/Line-related issues**. Among these, **citrate-induced hypocalcemia** is one of the most common acute complications during the procedure. It is managed by slowing the procedure, giving oral calcium, or in severe cases, intravenous calcium. Other options like hyperviscosity or delayed hemolysis are not typical complications of TPE itself.
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