Foundations of HIV Prevention in Zambia
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Propranolol blocks beta-adrenergic receptors, which normally increase heart rate and contractility when activated by adrenaline. Glucagon does not act on the same receptors. It activates its own (glucagon) receptors on heart cells, which also increases contractility through a different signaling pathway (increasing cAMP). Since they act through separate, non-interacting receptors to produce opposite functional effects on the same outcome (heart contractility), this is functional antagonism.
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