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Module Progress: Frozen Sections and Cryostat Technique

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Frozen Sections and Cryostat Technique

question 1 of 25 course: Biomedical Science(Degree)
question 1 of 25 course: Biomedical Science(Degree)

Q: A 'frozen section' is typically cut thinner than a routine paraffin section.

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PDK1 (3-phosphoinositide-dependent protein kinase-1) contains a PH domain that specifically binds to PIP3 at the plasma membrane. This recruitment to the membrane is essential for PDK1 to access and phosphorylate its key substrate, AKT, on threonine 308, which is a critical step in AKT activation.

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Did You Know?

PDK1 (3-phosphoinositide-dependent protein kinase-1) contains a PH domain that specifically binds to PIP3 at the plasma membrane. This recruitment to the membrane is essential for PDK1 to access and phosphorylate its key substrate, AKT, on threonine 308, which is a critical step in AKT activation.

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