Future Directions in Parasite Control
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This statement is true. Newborns have very low levels of immunoglobulins. The development of 'naturally occurring' anti-A and anti-B antibodies is not innate but is stimulated by environmental exposure. Beginning in early infancy, bacteria colonizing the gastrointestinal tract express polysaccharides on their surfaces that are structurally similar to the A and B blood group antigens. When an infant who lacks a particular antigen (e.g., a type A infant lacks B antigen) is exposed to these bacteria, their immune system mounts a response, producing IgM antibodies against the bacterial polysaccharide that cross-react with the corresponding human blood group antigen (e.g., anti-B).
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