True. This is a major mechanism of PI3K activation. The p85 regulatory subunit of PI3K contains SH2 domains that specifically bind to phospho-tyrosine motifs (e.g., pYXXM) on activated RTKs or their adaptor proteins (like IRS-1). This recruitment brings the catalytic p110 subunit to the membrane near its lipid substrate, PIP2, and also relieves p85's inhibitory hold on p110, leading to PI3K activation.

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