Global Onchocerciasis Control Programs
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True. STAT3 is frequently constitutively activated in cancers and drives the expression of genes promoting cell cycle progression (e.g., Cyclin D1), survival (e.g., Bcl-2), and angiogenesis (e.g., VEGF). In contrast, STAT1 is often activated by interferons and can promote anti-proliferative and pro-apoptotic responses, acting in a tumor-suppressive manner in many contexts.
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