Gram-Positive Rods: Pathogens
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Iron deficiency develops in stages. In the final, established stage of iron deficiency anemia, the body's iron stores are completely depleted. This is reflected in a very low serum ferritin (the storage protein). With no iron available, less iron is transported in the blood, so serum iron is low. In response to the low iron, the liver increases production of transferrin (the transport protein) to try to scavenge more iron, so the Total Iron-Binding Capacity (TIBC) is high. The Transferrin saturation (serum iron / TIBC x 100%) is therefore very low. This classic triad—low ferritin, low serum iron, high TIBC, and very low saturation—is diagnostic of iron deficiency anemia.
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