Hepatotoxicity

Hepatotoxicity, or drug-induced liver injury (DILI), is a major topic of high clinical relevance for tertiary students in medicine, pharmacy, toxicology, and biomedical laboratory science in Zambia. This module covers liver physiology, the mechanisms of hepatic injury (e.g., necrosis, steatosis, cholestasis, cirrhosis), and the role of bioactivation/detoxification balance. It details specific hepatotoxicants like acetaminophen, ethanol, and industrial chemicals. For Zambian university and college learners, mastering hepatotoxicity is crucial for understanding a leading cause of drug attrition, diagnosing liver disease, and managing poisoning cases. Excelling in this area prepares students for advanced examinations and careers in hepatology, clinical pharmacology, pharmaceutical safety, and public health, where they can contribute to reducing liver disease burden in Zambia.