University revision · Clinical Biochemistry

Inborn Errors of Metabolism Screening

Question 1 of 6 Course: Biomedical Science(Degree)

Which of the following are typically included in newborn screening?

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ERK is the terminal serine/threonine kinase in the canonical MAPK cascade. Once activated by MEK phosphorylation, ERK translocates to the nucleus where it phosphorylates a wide array of substrates. Its primary function is to phosphorylate and regulate transcription factors (like Elk-1, c-Myc, c-Fos) and other nuclear proteins. This leads to changes in gene expression that drive fundamental cellular processes, most notably cell proliferation and differentiation, but also survival and metabolism.

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