Introduction to the Immune System: Cells and Tissues
Q: Which cell type is considered the most efficient antigen-presenting cell for initiating a primary T cell response?
Did You Know?
A fundamental difference is their genomic structure and replication. HBV is a partially double-stranded DNA virus that replicates via an RNA intermediate and reverse transcription. Its DNA can integrate into the host genome, potentially causing insertional mutagenesis. HCV is a positive-sense single-stranded RNA virus that replicates entirely in the cytoplasm and does not integrate. Thus, while both cause chronic hepatitis and cirrhosis, HBV has an additional direct mutagenic mechanism via integration.
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