Insulin resistance is the pathological condition in which the body's cells (especially in liver, muscle, and fat tissue) fail to respond normally to insulin. Despite normal or high levels of insulin, glucose uptake is impaired, leading to compensatory hyperinsulinemia as the pancreas tries to overcome the resistance. Insulin resistance is the core defect in Metabolic Syndrome and is a major risk factor for the development of Type 2 Diabetes Mellitus. It is also associated with obesity, hypertension, dyslipidemia (high triglycerides, low HDL), polycystic ovary syndrome (PCOS), and non-alcoholic fatty liver disease (NAFLD). The exact causes are multifactorial, involving genetic predisposition, obesity (especially visceral fat), physical inactivity, and diet. Over time, insulin resistance can progress to beta-cell failure and overt diabetes.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies