This statement is true. Under the traditional Gleason scoring system (and reflected in the modern Grade Groups), a Gleason score of 4+3=7 is considered more aggressive and carries a worse prognosis than a score of 3+4=7, even though the sum is the same. This is because the first number (the primary pattern) represents the most common pattern seen in the tumor. A primary pattern of 4 (poorly formed or fused glands) indicates a less differentiated, more aggressive component driving the tumor's behavior, compared to a primary pattern of 3 (well-formed glands). Therefore, the order matters significantly. In current practice, 3+4=7 is classified as Grade Group 2 (favorable intermediate risk), while 4+3=7 is Grade Group 3 (unfavorable intermediate risk), leading to different management considerations.

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Zambia

• loveness Phiri – 722 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies