University revision · Nutrition and Dietetics

Macronutrients: Carbohydrates, Proteins, and Fats

Question 1 of 40 Course: Biomedical Science(Degree)

What is the primary storage form of carbohydrate in the human body?

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True. A 'nuclear' staining pattern, where the colored precipitate is confined to the cell nucleus (often with a speckled, diffuse, or nucleolar sub-pattern), is indeed expected for proteins whose primary function is within the nucleus. This includes: 1) **Transcription factors**: Proteins like p53, estrogen receptor (ER), progesterone receptor (PR), and MYC that regulate gene expression by binding DNA. 2) **Cell cycle-related proteins**: Markers of proliferation such as Ki-67 (which stains all active phases of the cell cycle except G0) and proteins involved in DNA replication and repair. 3) **Nuclear structural proteins** and components of the nuclear matrix. Observing a nuclear pattern provides immediate functional clues about the antigen. For example, in breast cancer diagnostics, nuclear staining for ER and PR is a positive result that guides hormonal therapy. The pattern must be distinguished from non-specific uptake of stain by necrotic nuclei or from background artifacts.

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