Three-dimensional glandular clusters with nuclear overlapping and prominent macronucleoli help distinguish adenocarcinoma from reactive bronchial cells in respiratory cytology. Adenocarcinoma cells form tight, three-dimensional groups with loss of polarity, while reactive cells maintain flat sheets or honeycomb patterns. Adenocarcinoma nuclei are often eccentric with irregular membranes and prominent, sometimes multiple, nucleoli; reactive cells have central nuclei with regular membranes and less prominent nucleoli. Cytoplasmic vacuolation (often containing mucin) is more characteristic of adenocarcinoma. These features, especially in combination, suggest malignancy over reactive change.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies