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Metals in Toxicology

question 1 of 18 course: Biomedical Science(Degree)
question 1 of 18 course: Biomedical Science(Degree)

Q: Which of the following is a common toxic mechanism shared by many metals?

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The t(8;14)(q24;q32) translocation is the hallmark genetic alteration in Burkitt lymphoma. It moves the MYC proto-oncogene from chromosome 8 into the immunoglobulin heavy chain (IgH) locus on chromosome 14. This places MYC under the control of the powerful IgH enhancer, leading to its constitutive overexpression. MYC is a master transcription factor that drives cell growth, proliferation, and metabolism. This dysregulation is a central driver of the aggressive B-cell proliferation seen in Burkitt lymphoma. Variant translocations involve immunoglobulin light chain loci (t(2;8) or t(8;22)).

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Did You Know?

The t(8;14)(q24;q32) translocation is the hallmark genetic alteration in Burkitt lymphoma. It moves the MYC proto-oncogene from chromosome 8 into the immunoglobulin heavy chain (IgH) locus on chromosome 14. This places MYC under the control of the powerful IgH enhancer, leading to its constitutive overexpression. MYC is a master transcription factor that drives cell growth, proliferation, and metabolism. This dysregulation is a central driver of the aggressive B-cell proliferation seen in Burkitt lymphoma. Variant translocations involve immunoglobulin light chain loci (t(2;8) or t(8;22)).

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