Wiskott-Aldrich Syndrome (WAS) is a rare **X-linked primary immunodeficiency** characterized by eczema, thrombocytopenia, and recurrent infections. The underlying defect is in the **WAS protein**, leading to **severe T-cell dysfunction** and impaired cellular immunity. Because of this profound T-cell immunodeficiency, patients with WAS are at **high risk for Transfusion-Associated Graft-versus-Host Disease (TA-GVHD)**. Viable donor T-lymphocytes present in non-irradiated cellular blood products (RBCs, platelets) can engraft in the immunocompromised recipient, recognize host tissues as foreign, and mount a lethal attack. Therefore, **all cellular blood products for patients with WAS must be irradiated** to inactivate donor lymphocytes. They may also benefit from **CMV-safe** and **leukoreduced** products. This is a standard of care for many primary immunodeficiencies and other conditions with severe T-cell impairment.

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Zambia

• ivwananji siwale – 29 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies