True, but this requires clarification. The immunoglobulin heavy chain is one of the two types of polypeptide chains (the other being the light chain) that make up an antibody molecule. Each antibody has two identical heavy chains and two identical light chains. The variable region of the heavy chain (VH) pairs with the variable region of the light chain (VL) to form one of the two identical antigen-binding sites (Fab regions) of the antibody. Therefore, the heavy chain directly contributes to the structure and specificity of the antigen-binding site. The constant region of the heavy chain (CH) forms the Fc portion, which determines the antibody class (isotype) and mediates effector functions. So, while the entire heavy chain is not solely for antigen binding, its variable domain is an essential component of the antigen-binding site.

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• ivwananji siwale – 29 pts

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