Neurology: Myasthenia Gravis and Lambert-Eaton
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Loratadine is a competitive antagonist at histamine H1 receptors. In allergic reactions, histamine is released from mast cells and binds to H1 receptors, causing symptoms like itching, wheals, and vasodilation. Loratadine works by blocking these receptors in peripheral tissues (e.g., skin, respiratory tract), preventing histamine from exerting its effects, thereby relieving allergic symptoms.
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