Hemophilia A is an X-linked recessive disorder caused by a deficiency of clotting Factor VIII. Factor VIII is part of the intrinsic pathway. Therefore, the screening test for the intrinsic pathway, the Activated Partial Thromboplastin Time (APTT), is prolonged. The Prothrombin Time (PT), which tests the extrinsic and common pathways, is normal. The bleeding time, which tests primary hemostasis (platelets and vessels), is also normal because platelet function is not affected. The diagnosis is confirmed by a specific assay showing a low level of Factor VIII activity. Patients with hemophilia typically experience deep tissue bleeding, joint bleeding (hemarthrosis), and prolonged bleeding after injury or surgery, rather than the superficial mucosal bleeding more common in platelet disorders.

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Zambia

• Chita katowando – 271 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies