SUFU (Suppressor of Fused) is a key negative regulator of the Hedgehog pathway. In the absence of a Hedgehog signal, full-length GLI transcription factors are bound by SUFU in the cytoplasm. This interaction inhibits GLI's transcriptional activity and promotes its partial proteolytic processing into repressor forms. Upon pathway activation, SUFU's inhibition is relieved, allowing GLI to be converted into its activator form and translocate to the nucleus. Loss of SUFU function can lead to constitutive Hedgehog signaling.

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Zambia

• ivwananji siwale – 29 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies