Organophosphorus and Carbamate Insecticides
Q: What is the key mechanism of toxicity for organophosphate insecticides?
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v-FLIP (viral FLICE inhibitory protein) is a homolog of cellular c-FLIP. It potently inhibits apoptosis by blocking the activation of caspase-8 at the death-inducing signaling complex (DISC). By preventing programmed cell death, v-FLIP allows infected and genetically unstable cells to survive, accumulate further mutations, and proliferate.
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