SOCS (Suppressors of Cytokine Signaling) proteins are part of a classic negative feedback loop. Once STAT activation leads to their transcription, SOCS proteins act to inhibit the pathway. They do this primarily by binding to JAK kinases or cytokine receptors, blocking their activity or targeting them for degradation, thus turning off the signal and preventing runaway activation.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies