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University revision · Toxicology and Pharmacology

Pharmacology of NSAIDs and Selective COX-2 Inhibitors

Question 1 of 10 Course: Biomedical Science(Degree)
Q1
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) primarily work by inhibiting which enzyme?
Choose an answer, then submit to see the explanation.

About this topic

This essential pharmacology topic for Zambian tertiary students covers Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and their more selective counterparts. Students will learn the central mechanism of action: inhibition of cyclooxygenase (COX) enzymes, with a detailed comparison of constitutive COX-1 and inducible COX-2 isoforms. The module covers classic NSAIDs like aspirin, ibuprofen, and diclofenac, discussing their anti-inflammatory, analgesic, and antipyretic effects alongside significant adverse effects like GI ulceration and renal impairment. It then contrasts these with the COX-2 selective inhibitors ('Coxibs' like celecoxib), explaining their improved GI safety profile but associated cardiovascular risks. For students in nursing, pharmacy, and clinical medicine programs across Zambia, this knowledge is fundamental for the safe and effective management of pain, fever, and inflammatory conditions such as arthritis, which are commonly encountered in clinical practice.

What you'll practise (10 questions)

  1. What is the term for a drug that reduces fever?
  2. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) primarily work by inhibiting which enzyme?
  3. Selective COX-2 inhibitors (like celecoxib) have a lower risk of causing gastric ulcers compared to non-selective NSAIDs.
  4. The anti-inflammatory effect of NSAIDs is primarily due to the inhibition of the enzyme lipoxygenase. True or False?
  5. What is the primary mechanism by which NSAIDs exert their anti-inflammatory effect?
  6. Aspirin is contraindicated in children with viral infections due to the risk of Reye's syndrome.
  7. Which of the following is a unique, irreversible effect of aspirin on platelets?
  8. Ibuprofen is a propionic acid derivative NSAID commonly used for mild to moderate pain and fever.
  9. The major advantage of selective COX-2 inhibitors (coxibs) over traditional NSAIDs is:
  10. What is the name of the enzyme that converts arachidonic acid to prostaglandins and is inhibited by NSAIDs?

Answer each question above to see the correct answer and a full explanation.