This statement is true, but with a critical caveat. Individuals with the very rare Bombay phenotype have a mutation in the FUT1 gene, which means they cannot produce the H antigen, the essential precursor for A and B antigens. Since their red cells lack H, they cannot convert it to A or B antigens, regardless of their ABO genes. Therefore, in standard forward grouping, their red cells show no reaction with anti-A or anti-B, just like type O cells. However, the crucial difference is in their serum. Unlike type O individuals who have anti-A and anti-B, Bombay individuals have potent anti-H in addition to anti-A and anti-B. Anti-H reacts strongly with all red cells except other Bombay cells, making them universal recipients for no one and requiring blood from another Bombay donor. This is why the phenotype is dangerous if misidentified as simple type O.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies