Public Health & Community Medicine
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Potentiation occurs when one drug increases the effect of another, but they do not act on the same receptor or system. Here, cimetidine inhibits liver enzymes (CYP450) that normally break down diazepam. This pharmacokinetic interaction slows diazepam's metabolism, causing it to accumulate in the body and produce a stronger sedative effect than expected from the dose alone. The increased effect is due to higher drug levels, not a direct pharmacodynamic boost.
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