The APC (Adenomatous Polyposis Coli) protein is the central scaffold of the β-Catenin destruction complex. It binds β-Catenin and Axin, facilitating the sequential phosphorylation of β-Catenin by CK1 and GSK3β. This phosphorylation marks β-Catenin for ubiquitination and proteasomal degradation. Loss-of-function mutations in APC are a hallmark of colorectal cancer, leading to constitutive WNT signaling.

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Zambia

• Joseph Soko – 101 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies