University revision · Cellular Pathology

Silver Impregnation Techniques

Question 1 of 1 Course: Biomedical Science(Degree)

The Gordon and Sweets silver impregnation technique is used to demonstrate:

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The 'lace-collar' appearance in urine cytology refers to a distinctive pattern seen in benign umbrella cells (superficial urothelial cells) where small vacuoles line the cytoplasmic membrane, creating a lacy border. This feature helps distinguish these normal cells from malignant cells or squamous cells. Umbrella cells are often bi- or multinucleated with abundant cytoplasm and low N/C ratios. The lace-collar effect results from numerous small vacuoles at the cell surface and is a reassuring finding of benign urothelium. Its recognition prevents misclassification of these large cells as suspicious or malignant.

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