True. Congo Red staining is a histochemical stain, not an IHC stain, but it is a fundamental confirmatory test for amyloidosis that is often performed in conjunction with or alongside IHC evaluations. When Congo Red binds to the beta-pleated sheet structure of amyloid fibrils, it produces a characteristic optical property: under polarized light, the stained amyloid deposits exhibit a pathognomonic 'apple-green' birefringence (a green-yellow color with a Maltese cross pattern in some cases). This is a critical diagnostic feature. In practice, a pathologist might first screen a tissue with a standard H&E stain, suspect amyloid based on amorphous eosinophilic deposits, and then order a Congo Red stain for confirmation. Following this, IHC using antibodies against specific precursor proteins (like amyloid A protein, transthyretin, or lambda/kappa light chains) can be performed on serial sections to type the amyloid, which is essential for determining the underlying disease and guiding treatment.

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