Chronic Myeloid Leukaemia is a myeloproliferative neoplasm that is almost universally (over 95% of cases) associated with a specific genetic abnormality. This abnormality is a translocation between chromosomes 9 and 22, written as t(9;22). This translocation creates a shortened chromosome 22 called the Philadelphia chromosome. The genetic consequence is the formation of a novel fusion gene called BCR-ABL1, which produces a protein with unregulated tyrosine kinase activity. This protein drives the uncontrolled growth of myeloid cells, and its detection is crucial for both diagnosis and targeted therapy with drugs like imatinib.

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Zambia

• loveness Phiri – 1084 pts

• Visual Pathway Lesions
• Positive and Negative Symptoms
• Hallucinations and Delusions
• Antipsychotic Medications
• Emergency: Environmental Emergencies